Neutrophil gelatinase-associated lipocalin elimination by renal replacement therapy: minding the membrane!
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چکیده
منابع مشابه
Neutrophil gelatinase-associated lipocalin elimination by renal replacement therapy: minding the membrane!
The recently published data of Donadio in Critical Care provide convincing evidence that neutrophil gelatinaseassociated lipocalin (NGAL), an established key biomarker of acute kidney injury (AKI) in the critically ill, can be effectively removed by renal replacement therapy (RRT) [1]. His findings challenge recent work by Schilder et al. [2] and corroborate our concern regarding the potential ...
متن کاملIs neutrophil gelatinase-associated lipocalin unaffected by convective continuous renal replacement therapy? Definitely … maybe
Two recent studies published in Critical Care reported that plasma [1] and urinary [2] levels of neutrophil gelatinase-associated lipocalin (NGAL), an important biomarker for prediction and diagnosis of acute kidney injury, were not affected by continuous renal replacement therapy (CRRT). The investigators assessed NGAL elimination during continuous venovenous hemofiltration [1] and hemodiafilt...
متن کاملNeutrophil Gelatinase-Associated Lipocalin Levels During Pneumoperitoneum
BACKGROUND AND OBJECTIVES A temporary deterioration in renal function during pneumoperitoneum has been reported, but the extent is not known. A new marker for the early detection of renal injury, neutrophil gelatinase-associated lipocalin (NGAL), has been shown to increase in various conditions that affect renal function. This study was conducted to explore detrimental effects of pneumoperitone...
متن کاملNeutrophil Gelatinase-Associated Lipocalin and Kidney Diseases
Neutrophil gelatinase-associated lipocalin (NGAL) has emerged as one of the most promising biomarkers of renal epithelial injury. Numerous studies have presented the diagnostic and prognostic utility of urinary and plasma NGAL in patients with acute kidney injury, chronic kidney disease, renal injury after kidney transplantation, and other renal diseases. NGAL is a member of the lipocalin famil...
متن کاملDual action of neutrophil gelatinase-associated lipocalin.
Neutrophil gelatinase-associated lipocalin (NGAL) is expressed and secreted by immune cells, hepatocytes, and renal tubular cells in various pathologic states. NGAL exerts bacteriostatic effects, which are explained by its ability to capture and deplete siderophores, small iron-binding molecules that are synthesized by certain bacteria as a means of iron acquisition. Consistently, NGAL deficien...
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ژورنال
عنوان ژورنال: Critical Care
سال: 2016
ISSN: 1364-8535
DOI: 10.1186/s13054-016-1258-9